Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 7/20 | 0.57 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747322 | 0.86 | HTR1A (0.43) | METAP2 | |
| SCHEMBL5916582 | 0.80 | METAP2 (0.56) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501734 | 0.78 | METAP2 (0.76) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501284 | 0.76 | METAP2 (0.78) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10502183 | 0.73 | METAP2 (1.00) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10502816 | 0.73 | METAP2 (0.76) | METAP2MPIPHOSPHO1 | |
| SCHEMBL18818124 | 0.73 | METAP2 (1.00) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501563 | 0.71 | METAP2 (0.74) | METAP2MPIPHOSPHO1 | |
| SCHEMBL5916652 | 0.71 | METAP2 (0.57) | METAP2MPIPHOSPHO1 | |
| SCHEMBL28783438 | 0.70 | ALOX15 (0.46) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135569-A1 | Use of benzisoselenazolone compounds against ischemic myocardial damage | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2006-06-22 | — | — | US | claimed |
| EP-1541145-A1 | THE USE OF BENZISOSELENAZOLONE COMPOUNDS AGAINST ISCHEMIC MYOCARDIAL DAMAGE | Institute of Materia, Chinese Academy of Medical Sciences (CN) | 2005-06-15 | — | — | EP | claimed |
| US-20060135569-A1 | Use of benzisoselenazolone compounds against ischemic myocardial damage | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2006-06-22 | — | — | US | disclosed |
| EP-1541145-A1 | THE USE OF BENZISOSELENAZOLONE COMPOUNDS AGAINST ISCHEMIC MYOCARDIAL DAMAGE | Institute of Materia, Chinese Academy of Medical Sciences (CN) | 2005-06-15 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| US-4550168-A | Benzisoselenazolones and a process for the treatment of inflammatory diseases | A. NATTERMANN & CIE GMBH (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |
| EP-0100899-A2 | Benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1984-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135569-A1 | Use of benzisoselenazolone compounds against ischemic myocardial damage | TNNI3, TNNT2, MYLK2 | METAP2 4321/4885MPI 819/4885PHOSPHO1 3395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.