Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747528 | 0.82 | MAPK8 (0.41) | AURKARAB9AKDM4ENPC1MEN1 | |
| SCHEMBL5916780 | 0.82 | KDM4E (0.53) | AURKABCHEACHERAB9AKDM4E | |
| SCHEMBL10749211 | 0.75 | METAP2 (0.35) | BCHEACHEKDM4EPKMMEN1 | |
| SCHEMBL10747549 | 0.72 | METAP2 (0.35) | BCHEACHEKDM4EPKMMEN1 | |
| SCHEMBL10747112 | 0.70 | HRH3 (0.40) | BCHEACHERAB9AKDM4ENPC1 | |
| SCHEMBL10748283 | 0.70 | METAP2 (0.36) | BCHEACHEKDM4EPKMMEN1 | |
| SCHEMBL10501589 | 0.69 | METAP2 (0.61) | BCHEACHEKDM4EPKMMEN1 | |
| SCHEMBL20040367 | 0.68 | AURKA (0.69) | AURKABCHEACHERAB9AKDM4E | |
| SCHEMBL10747582 | 0.68 | METAP2 (0.40) | BCHEACHEKDM4EPKMMEN1 | |
| SCHEMBL10502470 | 0.67 | METAP2 (0.46) | BCHEACHEKDM4EPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |