Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916661 | 0.85 | MPI (0.50) | MAPK8MAPK9MAPK10METAP2NPY5R | |
| SCHEMBL10747356 | 0.82 | AURKA (0.44) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL10746112 | 0.72 | NPC1 (0.43) | METAP2MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL10501187 | 0.71 | METAP2 (0.45) | METAP2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10747549 | 0.70 | METAP2 (0.35) | METAP2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10747439 | 0.69 | METAP2 (0.40) | METAP2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10501737 | 0.68 | METAP2 (0.41) | METAP2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10501811 | 0.68 | MPI (0.48) | METAP2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL10746982 | 0.68 | NCF1 (0.50) | MEN1MAPTKMT2AKDM4EHSD17B10 | |
| SCHEMBL10502572 | 0.67 | METAP2 (0.47) | METAP2MEN1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |