Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748283 | 0.85 | METAP2 (0.36) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10746865 | 0.85 | METAP2 (0.55) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10746433 | 0.80 | KMT2A (0.38) | MAPTNPC1CYP1A2RAB9ASMN1; SMN2 | |
| SCHEMBL10746662 | 0.72 | METAP2 (0.38) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10501844 | 0.71 | METAP2 (0.66) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10501084 | 0.71 | METAP2 (0.68) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10501742 | 0.70 | METAP2 (0.47) | METAP2GLAMPIPHOSPHO1 | |
| SCHEMBL10746207 | 0.70 | MEN1 (0.47) | METAP2TP53CYP3A4MAPTCYP2C9 | |
| SCHEMBL10501361 | 0.70 | MPI (0.51) | METAP2MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10954133 | 0.69 | METAP2 (0.46) | METAP2TP53CYP3A4MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |