Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | RB1 | P06400 | 3/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746196 | 0.85 | NR2E1 (0.61) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL10746281 | 0.85 | NR2E1 (0.61) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL10746930 | 0.85 | NR2E1 (0.61) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL30463364 | 0.85 | NR2E1 (0.61) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL10747530 | 0.85 | NR2E1 (0.61) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL10746883 | 0.82 | NR2E1 (0.58) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL19414190 | 0.82 | NR2E1 (0.58) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL30463365 | 0.82 | NR2E1 (0.58) | NR2E1HTR2AHTR2CTP53HPGD | |
| SCHEMBL4902847 | 0.80 | SIRT1 (0.52) | NR2E1HTR2AHTR2C | |
| SCHEMBL4900711 | 0.80 | VPS4B (0.58) | HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | disclosed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | disclosed |
| US-4547576-A | Tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-15 | — | — | US | disclosed |
| EP-0115607-A1 | Tetrahydrocarbazol derivatives | MERCK PATENT GmbH (DE) | 1984-08-15 | — | — | EP | disclosed |