Sugi Predict

Sugi Predict / Targets / VPS4B

VPS4B

Vacuolar protein sorting-associated protein 4B · O75351 · VPS4B on Sugi Atlas →

153 patent compounds predicted against VPS4B, 101 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL24837125 SCHEMBL24837125 1.00 1/20
SCHEMBL4905309 SCHEMBL4905309 0.61 1/20
SCHEMBL4900652 SCHEMBL4900652 0.58 1/20
SCHEMBL4900711 SCHEMBL4900711 0.58 1/20
SCHEMBL5384502 SCHEMBL5384502 0.58 1/20
SCHEMBL25488446 SCHEMBL25488446 0.57 1/20
SCHEMBL4904352 SCHEMBL4904352 0.56 1/20
SCHEMBL4904570 SCHEMBL4904570 0.55 1/20
SCHEMBL2429520 SCHEMBL2429520 0.52 1/20
SCHEMBL4895910 SCHEMBL4895910 0.52 1/20
SCHEMBL4897652 SCHEMBL4897652 0.52 1/20
SCHEMBL4899304 SCHEMBL4899304 0.52 1/20
SCHEMBL4899580 SCHEMBL4899580 0.52 1/20
SCHEMBL4497186 SCHEMBL4497186 0.51 1/20
SCHEMBL2493068 SCHEMBL2493068 0.51 1/20
SCHEMBL2493069 SCHEMBL2493069 0.51 1/20
SCHEMBL2494312 SCHEMBL2494312 0.51 1/20
SCHEMBL2494316 SCHEMBL2494316 0.51 1/20
SCHEMBL14768417 SCHEMBL14768417 0.51 1/20
SCHEMBL4895761 SCHEMBL4895761 0.51 1/20

Clinical trials — most relevant to VPS4B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy PHASE2/PHASE3UNKNOWN
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Nilotinib in Huntington's Disease PHASE1UNKNOWN
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction EARLY_PHASE1RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Susceptibility Genes in Autism Spectrum Disorders nanCOMPLETED
The Natural History of Alpha-Mannosidosis nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Autophagy Bladder Cancer nanUNKNOWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts nanCOMPLETED
Study of Chediak-Higashi Syndrome nanRECRUITING
Registry Gangliosidoses nanUNKNOWN
Impact of Graft Steatosis on Post-operative Complications After Liver Transplantation nanCOMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer nanUNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Genotype-Phenotype Correlations of Late Infantile Neuronal Ceroid Lipofuscinosis nanCOMPLETED
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML) nanWITHDRAWN
Mucolipidosis Type IV Natural History Study nanACTIVE_NOT_RECRUITING
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a VPS4B binder may also engage these)

ProteinNameSimilarity
Q0VD48 — 1.000 Q0VD48 →
P46467 — 1.000 P46467 →
Q5R658 — 1.000 Q5R658 →
P52917 — 0.997 P52917 →
Q9ZNT0 — 0.997 Q9ZNT0 →
D0FH76 — 0.997 D0FH76 →
Q5AG40 — 0.997 Q5AG40 →
Q8VEJ9 — 0.995 Q8VEJ9 →
Q9UN37 — 0.992 Q9UN37 →
Q793F9 — 0.992 Q793F9 →
Q54PT2 — 0.990 Q54PT2 →
Q09803 — 0.990 Q09803 →
Q9P7J5 — 0.986 Q9P7J5 →
P03974 — 0.986 P03974 →
P28737 — 0.985 P28737 →
Q4R407 — 0.985 Q4R407 →
P54811 — 0.983 P54811 →
Q3UMC0 — 0.983 Q3UMC0 →
Q1HGK7 — 0.983 Q1HGK7 →
Q09769 — 0.983 Q09769 →
F6QV99 — 0.982 F6QV99 →
P32794 — 0.982 P32794 →
KATNA1 Katanin p60 ATPase-containing subunit A1 0.982 landscape →
Q9WV86 — 0.982 Q9WV86 →
P25694 — 0.982 P25694 →
P54609 — 0.982 P54609 →
Q6E0V2 — 0.982 Q6E0V2 →
Q9D5T0 — 0.982 Q9D5T0 →
Q5U3S1 — 0.982 Q5U3S1 →
B4F6J6 — 0.982 B4F6J6 →