Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 16/20 | 0.56 |
| ▸ | CDK4 | P11802 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CCND1 | P24385 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CCND3 | P30281 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744899 | 0.86 | CDK4 (0.49) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10746410 | 0.86 | PDE2A (0.52) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10748598 | 0.85 | CDK4 (0.48) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10748145 | 0.84 | DGAT1 (0.48) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10745653 | 0.83 | CDK4 (0.65) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10747950 | 0.82 | AMY1A (0.67) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10761778 | 0.81 | CDK4 (0.46) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10748660 | 0.81 | CDK4 (0.46) | AMY1ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL24140660 | 0.81 | AMY1A (0.57) | AMY1A | |
| SCHEMBL10745760 | 0.81 | CDK4 (0.48) | AMY1ACDK4CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4696931-A | CARDIOVASCULAR DISORDERS, CARDIOTONIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-09-29 | — | — | US | disclosed |
| US-4582837-A | Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity | DR. KARL THOMAE GMBH (DE) | 1986-04-15 | — | — | US | disclosed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |
| EP-0098448-A2 | Imidazole derivatives, their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | disclosed |