Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | WDR5 | P61964 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748933 | 0.85 | WDR5 (0.51) | HRH3WDR5LMNANPC1GAA | |
| SCHEMBL10751194 | 0.84 | HRH3 (0.47) | HRH3WDR5LMNANPC1GAA | |
| SCHEMBL10749506 | 0.81 | WDR5 (0.60) | HRH3WDR5LMNANPC1GAA | |
| SCHEMBL10746724 | 0.81 | WDR5 (0.44) | HRH3WDR5LMNANPC1GAA | |
| SCHEMBL10749754 | 0.81 | TLR9 (0.39) | HRH3TLR9TLR8TLR7POLB | |
| SCHEMBL10746461 | 0.78 | TLR9 (0.43) | WDR5LMNANPC1GAARAB9A | |
| SCHEMBL10750339 | 0.78 | TLR9 (0.38) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL10749623 | 0.78 | WDR5 (0.46) | HRH3WDR5LMNANPC1GAA | |
| SCHEMBL10792659 | 0.77 | TLR9 (0.38) | HRH3LMNANPC1GAARAB9A | |
| SCHEMBL10751190 | 0.77 | WDR5 (0.46) | HRH3WDR5LMNANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670445-A | VASODILATORS | ELI LILLY AND COMPANY (US) | 1987-06-02 | — | — | US | disclosed |
| US-4578387-A | VASODILATION; DERIVATIVES OF 2-PHENYL-5,6,7,8-TETRAHYDROIMADAZO/1,2-A/PYRAZINE | ELI LILLY AND COMPANY (US) | 1986-03-25 | — | — | US | disclosed |