Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749506 | 0.89 | WDR5 (0.60) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10751194 | 0.86 | HRH3 (0.47) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10748824 | 0.85 | HRH3 (0.44) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10751190 | 0.84 | WDR5 (0.46) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10746724 | 0.80 | WDR5 (0.44) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10749623 | 0.78 | WDR5 (0.46) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10747230 | 0.78 | WDR5 (0.46) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10750669 | 0.78 | WDR5 (0.53) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10746716 | 0.77 | WDR5 (0.45) | WDR5LMNANPC1RAB9AKMT2A | |
| SCHEMBL10748448 | 0.77 | ALDH1A1 (0.41) | WDR5LMNANPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670445-A | VASODILATORS | ELI LILLY AND COMPANY (US) | 1987-06-02 | — | — | US | disclosed |
| US-4578387-A | VASODILATION; DERIVATIVES OF 2-PHENYL-5,6,7,8-TETRAHYDROIMADAZO/1,2-A/PYRAZINE | ELI LILLY AND COMPANY (US) | 1986-03-25 | — | — | US | disclosed |