Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rimantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 2/20 | 0.82 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rimantadine SCHEMBL3719331 | 1.00 | SLC22A2 (0.82) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL2981 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL15532385 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL29908943 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL20409367 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL2982 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL40906 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL4366035 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL28108817 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL14973619 | 0.86 | SLC22A2 (0.90) | SLC22A2SLC47A1MAPTGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230172904-A1 | COMBINATION OF AN ANTIALLERGIC AGENT WITH MUSCARINIC ANTAGONIST AND/OR DOPAMINERGIC AGONIST FOR USE IN PREVENTING/STOPPING OF AXIAL MYOPIA IN HUMAN | DAMBROSIO ENZO MARIA (IT) | 2023-06-08 | — | — | US | disclosed |
| CN-110426462-B | Method for detecting amantadine, rimantadine and memantine residues in animal derived food | 佛山科学技术学院 | 2022-07-12 | — | — | CN | disclosed |
| WO-2021122957-A1 | DENTAL ROOT CANAL FILLING COMPOSITION | DENTSPLY DETREY GMBH (DE) | 2021-06-24 | — | — | WO | disclosed |
| US-20200253951-A1 | COMBINATION OF AN ANTIALLERGIC AGENT WITH MUSCARINIC ANTAGONIST AND/OR DOPAMINERGIC AGONIST FOR USE IN PREVENTING/STOPPING OF AXIAL MYOPIA IN HUMAN | D'AMBROSIO ENZO MARIA (IT) | 2020-08-13 | — | — | US | disclosed |
| CN-109580603-A | A kind of detection and identification method of Ribavirin | 广州安诺科技股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| EP-3416617-A1 | COMBINATION OF AN ANTIALLERGIC AGENT WITH MUSCARINIC ANTAGONIST AND/OR DOPAMINERGIC AGONIST FOR USE IN PREVENTING/STOPPING OF AXIAL MYOPIA IN HUMAN | D'Ambrosio, Enzo Maria (IT) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017140846-A1 | COMBINATION OF AN ANTIALLERGIC AGENT WITH MUSCARINIC ANTAGONIST AND/OR DOPAMINERGIC AGONIST FOR USE IN PREVENTING/STOPPING OF AXIAL MYOPIA IN HUMAN | D'AMBROSIO ENZO MARIA (IT) | 2017-08-24 | — | — | WO | disclosed |
| WO-2011001258-A1 | COMPOSITIONS, METHODS, AND KITS FOR TREATING VIRAL AND BACTERIAL INFECTIONS BY TOCOTRIENOLS, TOCOMONOENOLS, TOCODIENOLS, TOCOPHEROLS, AND THEIR DERIVATES | EVITA LIFE SCIENCE PTE. LTD (SG) | 2011-01-06 | — | — | WO | disclosed |
| CN-101862345-A | The modified nucleosides that is used for the treatment of viral infection and abnormal cell proliferation | PHARMASSET LTD | 2010-10-20 | — | — | CN | disclosed |
| CN-1950069-A | Anti-excititoxic sustained release intracular implants and related methods | ALLERGAN INC (US) | 2007-04-18 | — | — | CN | disclosed |
| CN-1646141-A | Modified nucleosides for treating viral infections and abnormal cell proliferation | PHARMASSET LTD (BB) | 2005-07-27 | — | — | CN | disclosed |