Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.35 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075504 | 0.76 | MEN1 (0.39) | SMN1; SMN2NPC1GAAMAPTPIK3CA | |
| SCHEMBL1026474 | 0.76 | ALDH1A1 (0.40) | SMN1; SMN2NPC1ABL1CSF1RBCR | |
| SCHEMBL13622522 | 0.70 | ALDH1A1 (0.39) | SMN1; SMN2GAAMAPTABL1CSF1R | |
| SCHEMBL1026864 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2NPC1MAPTHTTMAPK1 | |
| SCHEMBL1026865 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2NPC1MAPTHTTMAPK1 | |
| SCHEMBL7702830 | 0.68 | NPC1 (0.45) | PDE2ASMN1; SMN2NPC1 | |
| SCHEMBL15640887 | 0.67 | SIGMAR1 (0.47) | NPC1CRHBPCRHR2RECQL | |
| SCHEMBL17536983 | 0.66 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1GAAMAPTTP53 | |
| SCHEMBL1025212 | 0.65 | MAPT (0.52) | SMN1; SMN2NPC1MAPTMAPK1RAB9A | |
| SCHEMBL1025211 | 0.65 | MAPT (0.52) | SMN1; SMN2NPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |