SCHEMBL10754355

SCHEMBL10754355

Cc1cc(Oc2ccc(Cl)cc2Br)c(Cl)c(Cl)c1NC(=O)NC(=O)c1ccccc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
NPC1 O15118 5/20 0.42
RAB9A P51151 5/20 0.42
PNLIP P16233 1/20 0.42
PYGL P06737 3/20 0.41
PPIA P62937 1/20 0.41
KCNMA1 Q12791 1/20 0.40
HPGD P15428 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 1/20 0.40
ATM Q13315 1/20 0.39
GCGR P47871 1/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.38
PARP1 P09874 1/20 0.37
PARG Q86W56 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8657045 0.94 LMNA (0.45) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8659354 0.91 LMNA (0.47) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8658068 0.91 LMNA (0.45) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL10756855 0.90 PNLIP (0.50) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL10752444 0.90 MEN1 (0.43) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8659406 0.86 KMT2A (0.42) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8657616 0.84 GCGR (0.48) KMT2AMEN1NPC1RAB9APNLIP
SCHEMBL9135305 0.84 PNLIP (0.49) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8660912 0.84 KMT2A (0.43) LMNANPSR1L3MBTL1KMT2AMEN1
SCHEMBL8659375 0.83 TP53 (0.45) LMNANPSR1L3MBTL1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215056-A1 PESTICIDAL 1-(4-PHENOXYPHENYL)-3-BENZOYL UREA COMPOUNDS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1987-03-25 EP claimed
WO-1986005781-A1 PESTICIDAL 1-(4-PHENOXYPHENYL)-3-BENZOYL UREA COMPOUNDS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1986-10-09 WO claimed