Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 3/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 2/20 | 0.30 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10760034 | 0.94 | TMEM97 (0.38) | TMEM97SIGMAR1NAMPTHCRTR2HCRTR1 | |
| SCHEMBL10755417 | 0.82 | TMEM97 (0.34) | TMEM97SIGMAR1NAMPTMAPK14 | |
| SCHEMBL10758766 | 0.82 | PPARG (0.38) | TMEM97SIGMAR1PPARAPPARG | |
| SCHEMBL10757335 | 0.80 | TMEM97 (0.34) | TMEM97SIGMAR1NAMPTHCRTR2HCRTR1 | |
| SCHEMBL10759693 | 0.79 | PPARG (0.39) | TMEM97SIGMAR1PPARAMAPK14PPARG | |
| SCHEMBL10758522 | 0.79 | EPHX2 (0.40) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10755422 | 0.76 | NAMPT (0.34) | TMEM97SIGMAR1NAMPTMAPK14 | |
| SCHEMBL10759260 | 0.76 | TMEM97 (0.41) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10759256 | 0.76 | TMEM97 (0.41) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10757112 | 0.76 | TMEM97 (0.36) | TMEM97SIGMAR1NAMPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |