Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10757342 | 0.94 | TMEM97 (0.36) | TMEM97SIGMAR1NAMPTHCRTR2HCRTR1 | |
| SCHEMBL10759260 | 0.82 | TMEM97 (0.41) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10759256 | 0.82 | TMEM97 (0.41) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10757112 | 0.82 | TMEM97 (0.36) | TMEM97SIGMAR1NAMPTMAPK14CA2 | |
| SCHEMBL10754804 | 0.82 | TMEM97 (0.36) | TMEM97SIGMAR1NAMPTMAPK14CA2 | |
| SCHEMBL10759693 | 0.81 | PPARG (0.39) | TMEM97SIGMAR1MAPK14HTR1AADRA1D | |
| SCHEMBL10758766 | 0.80 | PPARG (0.38) | TMEM97SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL10760027 | 0.79 | TMEM97 (0.35) | TMEM97SIGMAR1NAMPTHCRTR2HCRTR1 | |
| SCHEMBL10758227 | 0.78 | EPHX2 (0.41) | TMEM97SIGMAR1NAMPT | |
| SCHEMBL10755417 | 0.75 | TMEM97 (0.34) | TMEM97SIGMAR1NAMPTMAPK14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |