Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10757454 | 0.82 | CASP6 (0.40) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9139375 | 0.82 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL10757385 | 0.82 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL9138225 | 0.81 | PDE4A (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8807534 | 0.80 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8807651 | 0.80 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8811078 | 0.80 | PDE4A (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8810430 | 0.80 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9127881 | 0.80 | CYP11B1 (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10759518 | 0.79 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093535-B1 | NOVEL CHROMENES AND CHROMANS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | claimed |
| EP-0093535-A1 | Novel chromenes and chromans | BEECHAM GROUP PLC (GB) | 1983-11-09 | — | — | EP | claimed |
| US-4647670-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-03 | — | — | US | disclosed |
| EP-0093535-B1 | NOVEL CHROMENES AND CHROMANS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4510152-A | Antihypertensive chromenes and chromans | BEECHAM GROUP P.L.C. (GB) | 1985-04-09 | — | — | US | disclosed |
| EP-0093535-A1 | Novel chromenes and chromans | BEECHAM GROUP PLC (GB) | 1983-11-09 | — | — | EP | disclosed |