Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10759328 | 0.76 | GSK3A (0.35) | GSK3BGSK3ATSHRSMN1; SMN2MAPT | |
| SCHEMBL10755749 | 0.72 | MAPT (0.53) | GSK3BTSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL10755753 | 0.72 | MAPT (0.53) | GSK3BTSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL10762108 | 0.70 | KMT2A (0.44) | GSK3BGSK3ATSHRSMN1; SMN2MAPT | |
| SCHEMBL10762105 | 0.70 | KMT2A (0.44) | GSK3BGSK3ATSHRSMN1; SMN2MAPT | |
| SCHEMBL10755226 | 0.69 | TSHR (0.50) | TSHRSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL3192674 | 0.63 | TSHR (0.65) | TSHRSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL3213294 | 0.61 | TSHR (0.57) | TSHRSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL11678862 | 0.60 | HSD17B10 (0.41) | TSHRSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL29720508 | 0.60 | TSHR (0.59) | TSHRSMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |