Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10755753 | 1.00 | MAPT (0.53) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10759390 | 0.83 | KMT2A (0.52) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10759394 | 0.83 | KMT2A (0.52) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10762108 | 0.76 | KMT2A (0.44) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10762105 | 0.76 | KMT2A (0.44) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10759322 | 0.72 | GSK3B (0.36) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL10755226 | 0.72 | TSHR (0.50) | MAPTLMNARECQLMEN1KMT2A | |
| SCHEMBL10759328 | 0.71 | GSK3A (0.35) | MAPTLMNARECQLMCL1MEN1 | |
| SCHEMBL3468037 | 0.71 | HPGD (0.55) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL3468039 | 0.71 | HPGD (0.55) | MAPTLMNAMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |