Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | CDC25C | P30307 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | GPR3 | P46089 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28841465 | 0.89 | CCR6 (0.47) | CDC25ACDC25CCCR6HKDC1KDM4E | |
| SCHEMBL7726806 | 0.82 | CDC25A (0.51) | CDC25ACDC25CCCR6HKDC1KDM4E | |
| SCHEMBL2905321 | 0.74 | KDM4E (0.42) | CCR6HKDC1KDM4EALDH1A1LMNA | |
| SCHEMBL10441522 | 0.73 | ALDH1A1 (0.41) | CCR6HKDC1KDM4EALDH1A1LMNA | |
| Carbazole SCHEMBL28181847 | 0.71 | ALDH1A1 (0.61) | CDC25ACDC25CCCR6HKDC1KDM4E | |
| SCHEMBL20476303 | 0.71 | KDM4E (0.46) | CDC25ACDC25CCCR6HKDC1KDM4E | |
| SCHEMBL21561768 | 0.70 | ALDH1A1 (0.56) | KDM4EALDH1A1LMNAHPGDGAA | |
| SCHEMBL3151147 | 0.69 | KDM4E (0.50) | CDC25ACDC25CCCR6HKDC1KDM4E | |
| SCHEMBL17183623 | 0.69 | CDC25A (0.68) | CDC25ACDC25CHKDC1KDM4EALDH1A1 | |
| SCHEMBL3055898 | 0.69 | KDM4E (0.45) | KDM4EALDH1A1LMNAHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4707484-A | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives | HOFFMANN-LA ROCHE INC. (US) | 1987-11-17 | — | — | US | disclosed |
| US-4707484-A | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives | HOFFMANN-LA ROCHE INC. (US) | 1987-11-17 | — | — | US | disclosed |