Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.48 |
| ▸ | MAOB | P27338 | 8/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765345 | 0.87 | PDE3B (0.56) | PDE3BPDE3AMAOBCA12CA2 | |
| SCHEMBL10761951 | 0.84 | NPC1 (0.48) | PDE3BPDE3APTGS2PTGS1GPR119 | |
| SCHEMBL10763704 | 0.82 | PDE3A (0.47) | PDE3BPDE3ACA12CA2CA9 | |
| SCHEMBL10762324 | 0.81 | MAOB (0.43) | PDE3BPDE3AMAOBCA12CA2 | |
| SCHEMBL10763644 | 0.81 | PDE3B (0.37) | PDE3BPDE3AMAOBGPR119MAOA | |
| SCHEMBL10762047 | 0.80 | RELA (0.56) | PDE3BPDE3A | |
| SCHEMBL10763361 | 0.79 | PDE3B (0.46) | PDE3BPDE3AMAOBPTGS2PTGS1 | |
| SCHEMBL10764678 | 0.79 | PDE3B (0.43) | PDE3BPDE3AMAOBCA12CA2 | |
| SCHEMBL10764318 | 0.79 | PDE3B (0.57) | PDE3BPDE3AMAOBPTGS2PTGS1 | |
| SCHEMBL10765577 | 0.78 | PDE3B (0.47) | PDE3BPDE3AMAOBPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |