Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765360 | 0.84 | PDE3A (0.45) | PDE3BPDE3AGPR119CYP1A1CYP1A2 | |
| SCHEMBL10764480 | 0.82 | PDE3A (0.47) | PDE3BPDE3AGPR119CYP1A1CYP1A2 | |
| SCHEMBL10759920 | 0.81 | PDE3B (0.44) | PDE3BPDE3AGPR119F10PDE4A | |
| SCHEMBL10764989 | 0.81 | PDE3B (0.44) | PDE3BPDE3AGPR119F10PDE4A | |
| SCHEMBL10761240 | 0.80 | PDE3B (0.62) | PDE3BPDE3ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL10766164 | 0.79 | PDE3B (0.52) | PDE3BPDE3ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL10760321 | 0.76 | PDE3A (0.48) | PDE3BPDE3AGPR119PDE4BPBRM1 | |
| SCHEMBL10763860 | 0.75 | PDE3B (0.44) | PDE3BPDE3AGPR119CYP1A1CYP1A2 | |
| SCHEMBL10763163 | 0.73 | PDE3B (0.43) | PDE3BPDE3AGPR119CYP1A1CYP1A2 | |
| SCHEMBL10765163 | 0.72 | PDE3B (0.65) | PDE3BPDE3AGPR119PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | claimed |
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |