Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766164 | 0.85 | PDE3B (0.52) | PDE3BPDE3ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL10761737 | 0.85 | PDE3B (0.67) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761194 | 0.83 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10765163 | 0.83 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10759796 | 0.83 | PDE3B (0.69) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL7285568 | 0.83 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761216 | 0.83 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10765188 | 0.83 | PDE3B (0.56) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10765802 | 0.82 | PDE3B (0.55) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10767384 | 0.81 | PDE3B (0.62) | PDE3BPDE3ALMNARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | claimed |
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |