Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765723 | 0.86 | CREBBP (0.41) | PDE3BPDE3AAKR1C3AKR1C2PBRM1 | |
| SCHEMBL10764416 | 0.84 | PDE3A (0.40) | PDE3BPDE3APBRM1 | |
| SCHEMBL10762059 | 0.83 | PDE3B (0.41) | PDE3BPDE3APBRM1 | |
| SCHEMBL10764750 | 0.82 | PDE3B (0.41) | PDE3BPDE3APBRM1 | |
| SCHEMBL10760273 | 0.81 | PDE3B (0.42) | PDE3BPDE3AAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL10763441 | 0.81 | KDM4E (0.45) | PDE3BPDE3A | |
| SCHEMBL10765848 | 0.81 | PDE3A (0.35) | PDE3BPDE3A | |
| SCHEMBL10763665 | 0.80 | PDE3A (0.44) | PDE3BPDE3APTGS2 | |
| SCHEMBL10761782 | 0.80 | PDE3A (0.44) | PDE3BPDE3APTGS2 | |
| SCHEMBL10766451 | 0.80 | PDE3A (0.42) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |