Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764873 | 0.86 | PDE3B (0.37) | PDE3BPDE3APBRM1PDE4APDE4B | |
| SCHEMBL10761515 | 0.84 | PDE3B (0.38) | PDE3BPDE3APBRM1ALDH1A1PDE4A | |
| SCHEMBL10766286 | 0.83 | PDE3B (0.38) | PDE3BPDE3APBRM1ALDH1A1 | |
| SCHEMBL10763441 | 0.82 | KDM4E (0.45) | PDE3BPDE3AALDH1A1PDE4APDE4B | |
| SCHEMBL10760965 | 0.81 | PDE3B (0.41) | PDE3BPDE3APBRM1AKR1C3AKR1C2 | |
| SCHEMBL10765826 | 0.81 | PDE3A (0.36) | PDE3BPDE3AALDH1A1PDE4APDE4B | |
| SCHEMBL10764750 | 0.81 | PDE3B (0.41) | PDE3BPDE3APBRM1ALDH1A1PDE4A | |
| SCHEMBL10759628 | 0.80 | PDE3A (0.42) | PDE3BPDE3AALDH1A1PDE4APDE4B | |
| SCHEMBL10761958 | 0.80 | PDE4B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10760114 | 0.80 | PDE3A (0.42) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |