Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763361 | 0.87 | PDE3B (0.46) | PDE3BPDE3APBRM1PDE4APDE4B | |
| SCHEMBL10765188 | 0.83 | PDE3B (0.56) | PDE3BPDE3AGAAMAPTALDH1A1 | |
| SCHEMBL10761240 | 0.82 | PDE3B (0.62) | PDE3BPDE3AGAAMAPTALDH1A1 | |
| SCHEMBL10762902 | 0.80 | PDE3A (0.43) | PDE3BPDE3APBRM1PDE4BGPR119 | |
| SCHEMBL10765345 | 0.80 | PDE3B (0.56) | PDE3BPDE3ACA12CA1CA2 | |
| SCHEMBL10766286 | 0.79 | PDE3B (0.38) | PDE3BPDE3ACA12CA1CA2 | |
| SCHEMBL10759798 | 0.79 | PDE3B (0.59) | PDE3BPDE3AGAAMAPTLMNA | |
| SCHEMBL10763910 | 0.79 | PDE3B (0.54) | PDE3BPDE3AGAAMAPTALDH1A1 | |
| SCHEMBL10761737 | 0.78 | PDE3B (0.67) | PDE3BPDE3AGAAMAPTALDH1A1 | |
| SCHEMBL7285568 | 0.76 | PDE3B (0.65) | PDE3BPDE3AGAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |