Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NAMPT | P43490 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078165 | 0.85 | PTGER1 (0.43) | ALDH1A1GAATSHR | |
| SCHEMBL1078296 | 0.84 | PTGER1 (0.44) | ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL6199052 | 0.83 | HIF1A (0.42) | ALDH1A1KMT2ANOTUM | |
| SCHEMBL1074513 | 0.83 | PTGER1 (0.44) | ALDH1A1KMT2A | |
| SCHEMBL6203784 | 0.82 | TDP1 (0.39) | PKMKMT2ANPC1 | |
| SCHEMBL1078008 | 0.80 | KMT2A (0.43) | ALDH1A1KMT2ANPC1TSHR | |
| SCHEMBL6185927 | 0.74 | HPGD (0.43) | ALDH1A1PKMKMT2A | |
| SCHEMBL1037128 | 0.73 | HCRTR2 (0.73) | ALDH1A1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL6183374 | 0.70 | HCRTR1 (0.45) | NAMPTNPC1HCRTR1HCRTR2 | |
| SCHEMBL10053822 | 0.69 | HTT (0.66) | PKMKMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-B1 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-01-26 | — | — | EP | disclosed |