Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183808 | 0.84 | HCRTR2 (0.42) | MEN1KMT2A | |
| SCHEMBL1076164 | 0.82 | ALDH1A1 (0.54) | NPC1KMT2APKM | |
| SCHEMBL1078296 | 0.80 | PTGER1 (0.44) | HPGDPTGER1LMNAMEN1KMT2A | |
| SCHEMBL6199052 | 0.79 | HIF1A (0.42) | PTGER1PDE10ALMNAMEN1KMT2A | |
| SCHEMBL1078008 | 0.79 | KMT2A (0.43) | HPGDPTGER1NPC1RAB9AMEN1 | |
| SCHEMBL1078165 | 0.79 | PTGER1 (0.43) | HPGDPTGER1RAB9ALMNA | |
| SCHEMBL1074513 | 0.79 | PTGER1 (0.44) | PTGER1LMNAMEN1KMT2A | |
| SCHEMBL6185927 | 0.75 | HPGD (0.43) | HPGDRAB9AMEN1KMT2APKM | |
| SCHEMBL1039050 | 0.74 | HCRTR2 (0.52) | PTGER1MEN1KMT2ANPSR1 | |
| SCHEMBL1076948 | 0.69 | HCRTR1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-A2 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |