Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10767334 | 0.84 | PDE3A (0.50) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10765274 | 0.84 | PDE3B (0.53) | PDE3BPDE3ANFE2L2PBRM1PTGS1 | |
| SCHEMBL10764817 | 0.84 | PDE3A (0.50) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10760344 | 0.83 | PDE3A (0.47) | PDE3BPDE3ANFE2L2PBRM1RAB9A | |
| SCHEMBL10764372 | 0.82 | PTGS2 (0.60) | PDE3BPDE3ANFE2L2PTGS1PTGS2 | |
| SCHEMBL10760321 | 0.82 | PDE3A (0.48) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10760629 | 0.81 | CREBBP (0.54) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10764899 | 0.80 | PDE3B (0.52) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10764837 | 0.80 | PDE3A (0.46) | PDE3BPDE3APBRM1PTGS1PTGS2 | |
| SCHEMBL10761216 | 0.78 | PDE3B (0.65) | PDE3BPDE3ANFE2L2PBRM1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |