Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CSK | P41240 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764086 | 0.89 | PTGS1 (0.47) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10764456 | 0.86 | PTGS1 (0.45) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10767466 | 0.85 | PTGS1 (0.44) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10763419 | 0.83 | PDE3B (0.43) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10764678 | 0.83 | PDE3B (0.43) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10762546 | 0.82 | PDE3B (0.50) | PTGS2PTGS1PDE3BPDE3AGPR119 | |
| SCHEMBL10764817 | 0.82 | PDE3A (0.50) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10765274 | 0.82 | PDE3B (0.53) | PTGS2PTGS1PDE3BPDE3AGPR119 | |
| SCHEMBL10767334 | 0.82 | PDE3A (0.50) | PTGS2PTGS1PDE3BPDE3APDE4A | |
| SCHEMBL10765360 | 0.81 | PDE3A (0.45) | PTGS2PTGS1PDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |