Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10760750 | 0.99 | CHRNA7 (0.48) | CHRNA7ALDH1A1KDM4EDRD2GAA | |
| Hydrochloric Acid SCHEMBL10760747 | 0.99 | CHRNA7 (0.48) | CHRNA7ALDH1A1KDM4EDRD2GAA | |
| Hydrochloric Acid SCHEMBL10760739 | 0.99 | CHRNA7 (0.48) | CHRNA7ALDH1A1KDM4EDRD2GAA | |
| SCHEMBL10375773 | 0.94 | CHRNA7 (0.49) | CHRNA7ALDH1A1KDM4EDRD2GAA | |
| SCHEMBL10770146 | 0.82 | ALDH1A1 (0.50) | CHRNA7ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL13452591 | 0.82 | CHRNA7 (0.56) | CHRNA7ALDH1A1KDM4EDRD2 | |
| SCHEMBL13452486 | 0.81 | CHRNA7 (0.54) | CHRNA7ALDH1A1KDM4EDRD2 | |
| SCHEMBL27316877 | 0.80 | CHRNA7 (0.48) | CHRNA7ALDH1A1KDM4EDRD2HTR2C | |
| SCHEMBL23449208 | 0.79 | KDM4E (0.47) | CHRNA7ALDH1A1KDM4EDRD2HTR2C | |
| SCHEMBL13660581 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241292-A2 | 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates | McNeilab, Inc. (US) | 1987-10-14 | — | — | EP | claimed |
| US-4716172-A | 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates | MCNEILAB, INC. (US) | 1987-12-29 | — | — | US | disclosed |
| EP-0241292-A2 | 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates | McNeilab, Inc. (US) | 1987-10-14 | — | — | EP | disclosed |