Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | SI | P14410 | 3/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825436 | 0.83 | CA12 (0.43) | MAPTMAOBMAPK1THRATHRB | |
| SCHEMBL26635479 | 0.83 | THRA (0.45) | NPC1MAPTRAB9ATHRATHRB | |
| SCHEMBL26586960 | 0.81 | THRA (0.33) | NPC1MAPTRAB9ASMN1; SMN2MAOB | |
| SCHEMBL26635301 | 0.79 | THRA (0.51) | THRATHRB | |
| SCHEMBL26635406 | 0.79 | THRA (0.51) | THRATHRB | |
| SCHEMBL6322208 | 0.78 | NQO1 (0.50) | NPC1MAPTKDM4ETDP1 | |
| SCHEMBL25261232 | 0.77 | SMN1; SMN2 (0.49) | NPC1MAPTRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL25299247 | 0.77 | NSD2 (0.46) | NPC1MAPTRAB9ASMN1; SMN2APP | |
| SCHEMBL20556591 | 0.76 | RARB (0.44) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30176397 | 0.76 | SMN1; SMN2 (0.35) | MAPTSMN1; SMN2APPMAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228125-A1 | Novel derivatives of [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-07-08 | — | — | EP | disclosed |