Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764372 | 0.89 | PTGS2 (0.60) | PTGS1PTGS2NFE2L2PDE3BPDE3A | |
| SCHEMBL10764456 | 0.85 | PTGS1 (0.45) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10763566 | 0.85 | PDE3A (0.43) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10763333 | 0.84 | CREBBP (0.43) | PTGS1PTGS2PDE3BPDE3APDE4A | |
| SCHEMBL10767466 | 0.84 | PTGS1 (0.44) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10763120 | 0.83 | PDE3A (0.42) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10763264 | 0.79 | PDE3B (0.51) | PDE3BPDE3AKDM4EMAPTPDE4A | |
| SCHEMBL10763998 | 0.78 | PDE3A (0.43) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10764292 | 0.78 | PDE3A (0.43) | PTGS1PTGS2PDE3BPDE3AMAPT | |
| SCHEMBL10765392 | 0.77 | PDE3A (0.41) | PTGS1PTGS2PDE3BPDE3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |