Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 5/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | STAT3 | P40763 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10762692 | 0.90 | LMNA (0.64) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10765902 | 0.88 | SMN1; SMN2 (0.69) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10761723 | 0.83 | RAB9A (0.62) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10760888 | 0.82 | LMNA (0.60) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10764503 | 0.82 | SMN1; SMN2 (0.60) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL8965509 | 0.82 | LMNA (0.63) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10765472 | 0.81 | SMN1; SMN2 (0.62) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10763511 | 0.80 | SMN1; SMN2 (0.60) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10759679 | 0.79 | SMN1; SMN2 (0.59) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL10765198 | 0.79 | LMNA (0.59) | LMNARAB9ASMN1; SMN2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |