Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | PDE2A | O00408 | 3/20 | 0.55 |
| ▸ | PDE1A | P54750 | 2/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10762593 | 0.99 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10365546 | 0.79 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11080295 | 0.79 | CDC7 (0.38) | PDE3BPDE3ATSHRMAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL10366285 | 0.78 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10757838 | 0.78 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10761383 | 0.78 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10363627 | 0.78 | PDE3B (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10757069 | 0.77 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7341034 | 0.77 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL6052113 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |