Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765501 | 0.79 | PDE3B (0.62) | PDE3BPDE3ATSHRKMT2ACRBN | |
| Hydrochloric Acid SCHEMBL10762593 | 0.78 | PDE3B (0.61) | PDE3BPDE3ATSHRKMT2ACRBN | |
| SCHEMBL10757838 | 0.76 | PDE3B (0.52) | PDE3BPDE3AGAACYP19A1 | |
| SCHEMBL11089259 | 0.73 | PDE3B (0.41) | CDC7PDE3BPDE3AGAATSHR | |
| SCHEMBL11080028 | 0.71 | PDE3B (0.44) | CDC7PDE3BPDE3AGAACYP19A1 | |
| SCHEMBL11079732 | 0.68 | PDE3B (0.49) | CDC7PDE3BPDE3ACYP19A1CRBN | |
| SCHEMBL10363627 | 0.68 | PDE3B (0.42) | PDE3BPDE3ATSHRBRD4CREBBP | |
| SCHEMBL10365546 | 0.67 | PDE3B (0.44) | PDE3BPDE3ATSHRBRD4CREBBP | |
| SCHEMBL10367244 | 0.66 | PDE3B (0.51) | PDE3BPDE3AGAAKMT2AMAPT | |
| Ethane SCHEMBL10775108 | 0.65 | PDE3B (0.50) | PDE3BPDE3AGAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | claimed |
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4431651-A | 2-Pyridinones and their use as cardiotonic agents | STERLING DRUG INC. (US) | 1984-02-14 | — | — | US | disclosed |