Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764747 | 0.86 | PDE3A (0.50) | PDE3BPDE3AMAPTLMNAPDE4A | |
| SCHEMBL10761226 | 0.83 | PDE3A (0.49) | PDE3BPDE3AMAPTLMNAPDE4A | |
| SCHEMBL10763316 | 0.82 | PDE3B (0.50) | PDE3BPDE3AALDH1A1GALR3GAA | |
| SCHEMBL10766313 | 0.81 | PDE3B (0.60) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL10760816 | 0.81 | PDE3B (0.55) | PDE3BPDE3AALDH1A1GALR3GAA | |
| SCHEMBL10762400 | 0.80 | PDE3B (0.56) | PDE3BPDE3AALDH1A1PDE4APDE4B | |
| SCHEMBL10763936 | 0.80 | PDE3B (0.56) | PDE3BPDE3AMAPTGALR3PDE4A | |
| SCHEMBL10764837 | 0.79 | PDE3A (0.46) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL10765022 | 0.78 | PTGS2 (0.54) | PDE3BPDE3AMAPTLMNAGAA | |
| SCHEMBL10759796 | 0.78 | PDE3B (0.69) | PDE3BPDE3AMAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |