Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.70 |
| ▸ | MMP9 | P14780 | 3/20 | 0.70 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.70 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.70 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | STAT3 | P40763 | 2/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.70 |
| ▸ | RELA | Q04206 | 2/20 | 0.70 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766293 | 1.00 | APP (0.70) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL10764387 | 0.90 | LMNA (0.63) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL10764383 | 0.90 | LMNA (0.63) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL10764099 | 0.88 | LMNA (0.68) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL10764094 | 0.88 | LMNA (0.68) | APPPTGS2MMP9PRKCEPRKCQ | |
| Curcumin Pyrazole SCHEMBL9553585 | 0.82 | APP (1.00) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL8966189 | 0.82 | LMNA (0.63) | PTGS2MAPTNPC1LMNARAB9A | |
| Curcumin Pyrazole SCHEMBL13907614 | 0.82 | APP (1.00) | APPPTGS2MMP9PRKCEPRKCQ | |
| SCHEMBL10761840 | 0.82 | LMNA (0.63) | PTGS2MAPTNPC1LMNARAB9A | |
| Curcumin Pyrazole SCHEMBL29798918 | 0.82 | APP (1.00) | APPPTGS2MMP9PRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |