Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.51 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10760276 | 0.85 | PDE3B (0.61) | CREBBPPDE3BPDE3APTGS1PTGS2 | |
| SCHEMBL10766791 | 0.85 | PDE3B (0.46) | CREBBPPDE3BPDE3ABRD4PTGS1 | |
| SCHEMBL10765577 | 0.84 | PDE3B (0.47) | CREBBPPDE3BPDE3ABRD4PTGS1 | |
| SCHEMBL10765618 | 0.81 | PDE3B (0.54) | CREBBPPDE3BPDE3ABRD4PTGS1 | |
| SCHEMBL10764454 | 0.81 | PDE3B (0.54) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10764318 | 0.81 | PDE3B (0.57) | PDE3BPDE3APTGS1PTGS2PBRM1 | |
| SCHEMBL10764414 | 0.81 | PDE3B (0.54) | CREBBPPDE3BPDE3ABRD4PTGS1 | |
| SCHEMBL10761986 | 0.81 | PDE3A (0.47) | CREBBPPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10766164 | 0.80 | PDE3B (0.52) | CREBBPPDE3BPDE3ABRD4PTGS1 | |
| SCHEMBL10760816 | 0.79 | PDE3B (0.55) | CREBBPPDE3BPDE3ABRD4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |