Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765618 | 0.85 | PDE3B (0.54) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10764454 | 0.85 | PDE3B (0.54) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10764318 | 0.85 | PDE3B (0.57) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10761194 | 0.84 | PDE3B (0.65) | PDE3BPDE3AMAOBPBRM1PDE4A | |
| SCHEMBL10766164 | 0.82 | PDE3B (0.52) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10767320 | 0.81 | CREBBP (0.53) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10763204 | 0.81 | PDE3B (0.51) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10763316 | 0.81 | PDE3B (0.50) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10762047 | 0.79 | RELA (0.56) | PDE3BPDE3ACREBBPBRD4 | |
| SCHEMBL10761951 | 0.77 | NPC1 (0.48) | PDE3BPDE3APTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |