Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765555 | 0.92 | PDE3A (0.42) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10761038 | 0.82 | PDE3A (0.39) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10762076 | 0.82 | PBRM1 (0.36) | GPR119PDE3APDE3BSMN1; SMN2PDE4B | |
| SCHEMBL10761208 | 0.82 | PDE3A (0.41) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10762749 | 0.82 | PDE3A (0.39) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10766718 | 0.81 | PDE3A (0.35) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10760114 | 0.81 | PDE3A (0.42) | GPR119PDE3APDE3BSMN1; SMN2PDE4B | |
| SCHEMBL10763441 | 0.80 | KDM4E (0.45) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10763163 | 0.80 | PDE3B (0.43) | GPR119PDE3APDE3BABCB11MAOA | |
| SCHEMBL10760439 | 0.80 | PDE3A (0.41) | GPR119PDE3APDE3BABCB11MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |