Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766718 | 0.87 | PDE3A (0.35) | PBRM1PDE3APDE3BGPR119BRD4 | |
| SCHEMBL10764068 | 0.85 | PDE3B (0.33) | PBRM1PDE3APDE3BGPR119BRD4 | |
| SCHEMBL10765553 | 0.84 | PTGS2 (0.37) | PBRM1PDE3APDE3BGPR119BRD4 | |
| SCHEMBL10765555 | 0.82 | PDE3A (0.42) | PDE3APDE3BGPR119PDE4BMAPT | |
| SCHEMBL10767498 | 0.82 | GPR119 (0.41) | PDE3APDE3BGPR119PDE4BMAPT | |
| SCHEMBL10763440 | 0.80 | PDE3A (0.40) | PBRM1PDE3APDE3BGPR119PDE4B | |
| SCHEMBL10761238 | 0.80 | MAPT (0.41) | PBRM1PDE3APDE3BGPR119PDE4B | |
| SCHEMBL10762863 | 0.80 | BRD4 (0.41) | PBRM1PDE3APDE3BGPR119BRD4 | |
| SCHEMBL10760489 | 0.79 | PBRM1 (0.35) | PBRM1PDE3APDE3BGPR119BRD4 | |
| SCHEMBL10761208 | 0.79 | PDE3A (0.41) | PDE3APDE3BGPR119PDE4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |