Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29795069 | 0.76 | MAOA (0.46) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL5027873 | 0.76 | MAOA (0.46) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL27537222 | 0.74 | MAOA (0.44) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL28417393 | 0.73 | MAOA (0.43) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL472047 | 0.73 | MAOA (0.43) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL21367417 | 0.72 | MAOA (0.39) | MAOABCHECES1ALDH1A1HSD11B1 | |
| SCHEMBL6481957 | 0.72 | MAOA (0.65) | MAOABCHECES1ALDH1A1CASP3 | |
| Fluorene SCHEMBL27849096 | 0.72 | MAOA (0.65) | MAOABCHECES1ALDH1A1CASP3 | |
| Fluorene SCHEMBL17107853 | 0.72 | MAOA (0.65) | MAOABCHECES1ALDH1A1CASP3 | |
| Fluorene SCHEMBL19516585 | 0.72 | MAOA (0.65) | MAOABCHECES1ALDH1A1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228192-A2 | Renin-inhibitory oligopeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0186977-A2 | Renin-inhibitory dipeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-07-09 | — | — | EP | disclosed |