Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.49 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037048 | 0.81 | SLC6A4 (0.54) | SLC6A4HRH3 | |
| SCHEMBL1034562 | 0.78 | HRH3 (0.76) | SLC6A4HRH3 | |
| SCHEMBL6715276 | 0.78 | SLC6A4 (0.53) | SLC6A4HRH3 | |
| SCHEMBL1035603 | 0.77 | SLC6A4 (0.71) | SLC6A4HRH3 | |
| SCHEMBL1077401 | 0.76 | SLC6A4 (0.43) | SLC6A4HRH3EED | |
| Hydrochloric Acid SCHEMBL6632289 | 0.75 | HRH3 (0.55) | HRH3 | |
| SCHEMBL1035507 | 0.74 | SLC6A4 (0.77) | SLC6A4HRH3 | |
| SCHEMBL6614605 | 0.72 | NPY1R (0.42) | HRH3EEDACP1 | |
| SCHEMBL1036213 | 0.71 | SLC6A4 (0.61) | SLC6A4HRH3 | |
| SCHEMBL1034743 | 0.71 | SLC6A4 (0.73) | SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831173-B1 | TETRAHYDROISOQUINOLINE COMPOUNDS FOR TREATMENT OF CNS DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-26 | — | — | EP | disclosed |