Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.53 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL6846620 | 0.98 | GPR84 (0.52) | GPR84FFAR1MAPTLCKPPARD | |
| Hexane SCHEMBL6815543 | 0.98 | GPR84 (0.52) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL3955547 | 0.86 | GPR84 (0.46) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL337541 | 0.85 | GPR84 (0.57) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL8816556 | 0.85 | GPR84 (0.57) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL11390310 | 0.85 | GPR84 (0.57) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL27878051 | 0.85 | GPR84 (0.57) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL7295527 | 0.85 | GPR84 (0.57) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL29060815 | 0.84 | GPR84 (0.58) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL14761700 | 0.83 | GPR84 (0.55) | GPR84FFAR1MAPTLCKPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224183-A1 | 16, 17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SLECTIVE ESTROGENIC ACTIVITY | N.V. ORGANON (US) | 2011-09-15 | — | — | US | disclosed |
| US-7868193-B2 | 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity | N.V. ORGANON (NL) | 2011-01-11 | — | — | US | disclosed |
| US-20100249083-A1 | 16,17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY | N.V. ORGANON (US) | 2010-09-30 | — | — | US | disclosed |
| EP-1294739-B1 | 16,17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY | AKZO NOBEL NV (NL) | 2005-04-13 | — | — | EP | disclosed |
| US-20040102426-A1 | 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-05-27 | — | — | US | disclosed |
| EP-1294739-A1 | 16,17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY | Akzo Nobel N.V. (NL) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002000682-A1 | 16, 17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY | AKZO NOBEL N.V. (NL) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224183-A1 | 16, 17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SLECTIVE ESTROGENIC ACTIVITY | ESR2, ESRRA, ESR1 | GPR84 327/4885FFAR1 101/4885MAPT 4831/4885 |
| US-20100249083-A1 | 16,17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY | ESR2, ESRRA, ESR1 | GPR84 328/4885FFAR1 160/4885MAPT 4807/4885 |
| US-20040102426-A1 | 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity | ESR2, HSD17B11, ESRRA | GPR84 423/4885FFAR1 163/4885MAPT 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.