Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10774098 | 0.92 | LPAR1 (0.56) | LPAR1SMN1; SMN2KMT2AALDH1A1NPSR1 | |
| SCHEMBL10952099 | 0.82 | LPAR1 (0.59) | LPAR1SMN1; SMN2KMT2APTGESLMNA | |
| SCHEMBL10777744 | 0.81 | LMNA (0.60) | LPAR1SMN1; SMN2KMT2AALDH1A1NPSR1 | |
| SCHEMBL10780464 | 0.81 | LPAR1 (0.52) | LPAR1SMN1; SMN2KMT2AALDH1A1NPSR1 | |
| SCHEMBL10774313 | 0.81 | LPAR1 (0.61) | LPAR1SMN1; SMN2KMT2APTGESLMNA | |
| SCHEMBL30785333 | 0.77 | MEN1 (0.46) | LPAR1KMT2AALDH1A1LPAR5NPSR1 | |
| SCHEMBL10774304 | 0.76 | LPAR1 (0.56) | LPAR1SMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL6895421 | 0.76 | ALDH1A1 (0.42) | LPAR1ALDH1A1ACELMNA | |
| SCHEMBL30785328 | 0.74 | LPAR1 (0.44) | LPAR1KMT2AALDH1A1LPAR5NPSR1 | |
| SCHEMBL14854909 | 0.74 | NPC1 (0.61) | SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |