Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10772456 | 0.85 | DHFR (0.39) | DHFRTDP1GABRPGABRDGABRA1 | |
| SCHEMBL10773304 | 0.82 | TLR8 (0.43) | DHFRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10778377 | 0.81 | TDP1 (0.34) | DHFRTDP1GABRPGABRDGABRA1 | |
| SCHEMBL10776018 | 0.80 | ALDH1A1 (0.36) | DHFRTDP1ALDH1A1CYP1A2HCAR2 | |
| SCHEMBL13653845 | 0.76 | HEXA (0.41) | DHFRTDP1ALDH1A1CYP1A2HEXA | |
| SCHEMBL10775608 | 0.74 | CYP2D6 (0.50) | DHFRALDH1A1MAPT | |
| SCHEMBL27666925 | 0.73 | TDP1 (0.42) | TDP1ALDH1A1MAPTCYP1A2PDPK1 | |
| SCHEMBL5188179 | 0.71 | HCAR2 (0.41) | TDP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31751932 | 0.69 | TDP1 (0.44) | TDP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6298416 | 0.69 | HCAR2 (0.40) | TDP1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4689328-A | CARBOXY-PYRIMIDINE DERIVATIVES | RESEARCH CORPORATION (US) | 1987-08-25 | — | — | US | disclosed |