Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.37 |
| ▸ | HTR6 | P50406 | 9/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | QDPR | P09417 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786592 | 0.68 | HTR2C (0.36) | HTR2CSIGMAR1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL978347 | 0.67 | TDP1 (0.35) | HTR6CYP2D6 | |
| Hydrochloric Acid SCHEMBL979545 | 0.67 | TDP1 (0.35) | HTR6CYP2D6 | |
| Hydrochloric Acid SCHEMBL17455095 | 0.64 | HTR2C (0.57) | HTR2CHTR6SIGMAR1QDPR | |
| SCHEMBL23074510 | 0.62 | SIGMAR1 (0.46) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4261152 | 0.62 | HTR2C (0.56) | HTR2CSIGMAR1QDPR | |
| SCHEMBL20913198 | 0.61 | SIGMAR1 (0.60) | HTR2CHTR6SIGMAR1QDPR | |
| SCHEMBL9943846 | 0.59 | HTR2C (0.39) | HTR2CHTR6SIGMAR1QDPR | |
| SCHEMBL1080407 | 0.59 | RGS12 (0.30) | — | |
| SCHEMBL28399652 | 0.59 | HTR2C (0.46) | HTR2CHTR6SIGMAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454251-A1 | GPR119 AGONISTS | Eli Lilly and Company (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008663-A1 | GPR119 AGONISTS | ELI LILLY AND COMPANY (US) | 2011-01-20 | — | — | WO | disclosed |