Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | HPN | P05981 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779170 | 0.88 | CA2 (0.65) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL10779173 | 0.88 | CA2 (0.65) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL10779164 | 0.88 | CA2 (0.65) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL28625510 | 0.80 | ALDH1A1 (0.71) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL7325853 | 0.79 | CA2 (0.67) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL10779555 | 0.79 | CA2 (0.63) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL10779550 | 0.79 | CA2 (0.63) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL10779543 | 0.79 | CA2 (0.63) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL14544528 | 0.75 | ALDH1A1 (0.67) | ALDH1A1CA2CA7MMP2MMP9 | |
| SCHEMBL28615682 | 0.75 | ALDH1A1 (0.57) | ALDH1A1CA2CA7MMP9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716155-A | INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1987-12-29 | — | — | US | disclosed |
| EP-0083172-B1 | PHOSPHORUS CONTAINING COMPOUNDS | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4555506-A | Phosphorus containing compounds and use as hypotensives | E. R. SQUIBB & SONS, INC. (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0083172-A2 | Phosphorus containing compounds | E.R. Squibb & Sons, Inc. (US) | 1983-07-06 | — | — | EP | disclosed |