Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6938123 | 0.98 | TSHR (0.60) | TSHRALDH1A1HCAR2TP53EGLN1 | |
| Fumaric Acid SCHEMBL6938129 | 0.98 | TSHR (0.60) | TSHRALDH1A1HCAR2TP53EGLN1 | |
| Fumaric Acid SCHEMBL20293747 | 0.88 | TSHR (0.48) | TSHRALDH1A1HCAR2TP53EGLN1 | |
| Maleic Acid SCHEMBL11594855 | 0.86 | TSHR (0.67) | TSHRALDH1A1HCAR2TP53EGLN1 | |
| Fumaric Acid SCHEMBL11594861 | 0.86 | TSHR (0.67) | TSHRALDH1A1HCAR2TP53EGLN1 | |
| Acrylic Acid SCHEMBL28037712 | 0.85 | TSHR (0.63) | TSHRALDH1A1ABCC4MAPTLMNA | |
| Acrylic Acid SCHEMBL31572032 | 0.85 | TSHR (0.63) | TSHRALDH1A1ABCC4MAPTLMNA | |
| Bicarbonate SCHEMBL997243 | 0.85 | — | — | |
| Bicarbonate SCHEMBL31378512 | 0.85 | TSHR (0.71) | TSHRALDH1A1ABCC4MAPTLMNA | |
| Acetic Acid SCHEMBL28891258 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4652271-A | Coal suspension flowability improvers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1987-03-24 | — | — | US | disclosed |