Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778641 | 0.81 | MAPK8 (0.46) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL14690552 | 0.80 | MAPK8 (0.54) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL950258 | 0.80 | ATR (0.53) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL14874214 | 0.78 | KDM4E (0.59) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL30308930 | 0.77 | KDM4E (0.47) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL6770544 | 0.77 | RAB9A (0.55) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL25722015 | 0.77 | KDM4E (0.47) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL13818078 | 0.75 | MAPK8 (0.59) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL21767787 | 0.75 | KDM4E (0.56) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL10784392 | 0.74 | MAPK8 (0.49) | MAPK8MAPK9MAPK10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110484-B1 | DERIVATIVES OF AMINOPYRIDINECARBOXYLIC ACIDS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Simes S.p.A. (IT) | 1987-09-02 | — | — | EP | disclosed |
| US-4528296-A | Derivatives of aminopyridinecarboxylic acids and pharmaceutical compositions containing them | SIMES, SOCIETA ITALIANA MEDICINALLE SINTETICI (IT) | 1985-07-09 | — | — | US | disclosed |
| EP-0110484-A1 | Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them | Simes S.p.A. (IT) | 1984-06-13 | — | — | EP | disclosed |