Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771981 | 0.86 | SERPINE1 (0.60) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6108092 | 0.81 | TSHR (0.72) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21767689 | 0.79 | PTPN1 (0.48) | MAPTKDM4ELMNAHPGDNPC1 | |
| SCHEMBL16455939 | 0.78 | RAB9A (0.59) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4800345 | 0.77 | KDM4E (0.59) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14690552 | 0.77 | MAPK8 (0.54) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL31261245 | 0.77 | RAB9A (0.58) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22441103 | 0.77 | RAB9A (0.58) | RAB9AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6108626 | 0.77 | KDM4E (0.68) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10784388 | 0.77 | MAPK8 (0.49) | KDM4EALDH1A1LMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689780-B1 | PYRIDINE DERIVATIVES | ELI LILLY AND COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1140905-B1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-1140905-A1 | HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039117-A1 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |